In what appears to be a repeat of the 2013 FA Cup final, League One leaders, Wigan Athletic is hoping to make history once again, when they play Manchester City in the fifth- round draw.
The DW Stadium clash will stir memories of the 2013 final where Wigan, the first team to win the FA Cup and be relegated in the same season, bagged an impressive Cup win following a header by Ben Watson.
Four Premier league teams (Arsenal, Liverpool, West Ham and Wordford) have already been knocked out of the last leg of the challenge while Chelsea hope for home-ground advantage in the game against Hull City.
Notts County are expected to play Swansea where the winner will battle it out with Sheffield Wednesday.
FA Cup fifth-round draw
Sheffield Wednesday v Notts County/Swansea
West Brom v Southampton
Chelsea v Hull City
Leicester v Sheffield United
Huddersfield/Birmingham v Manchester United
Millwall/Rochdale v Newport/Tottenham
Brighton v Coventry
Wigan v Manchester City